Transcriptional Regulation of Sertoli Cell Immediate Early Genes by Interleukin-6 and Interferon-γ Is Mediated through Phosphorylation of STAT-3 and STAT-1 Proteins*

Induced Genes by Suppressing Tyrosine Phosphorylation of STAT 1 − γ and Interferon − Interleukin - 10 Inhibits Expression of Both Interferon ?

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IGF-I regulation by IFN-γ requires STAT-5b TRANSCRIPTIONAL REGULATION OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) BY INTERFERON-GAMMA (IFN-γ) REQUIRES STAT-5b

The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6.

Imiquimod is an oral inducer of interferon (IFN) and several other proinflammatory cytokines and has been successfully used topically as an antiviral agent for the treatment of genital warts. We have investigated the molecular mechanisms by which imiquimod induces the expression of IFNs, IFN-stimulated genes (ISGs), and proinflammatory cytokines in vivo, using mice deficient in various componen...

Interleukin 2 signaling involves the phosphorylation of Stat proteins.

One of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and natural killer cells. The mechanisms by which the effects of IL-2 are propagated within cells are not understood. While the binding of IL-2 to its receptor was recently shown to lead to the activation of two kinases, Jak-1 ...

Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.

The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2 heterodimer and a weak DNA-binding protein, p48, that is a member of a growing family of proteins similar to the so-called interferon regulatory factor (IRF-1). The p48 and Stat1:2 heterodimer do not associate stably in the absence of DNA, but we show that amino acids appro...